To use a Outlook.exe found using Windows Search, right click on the Outlook shortcut and choose Run as Administrator from the menu. When Outlook is pinned to the desktop Taskbar, hold Ctrl+Shift and right click on the Taskbar icon. You only need run as administrator one time, and once you make the change it will be in effect for all Outlook profiles on the computer. Note: To change the Programmatic Access setting in Outlook's Trust Center, you need to run Outlook as an Administrator. Programmatic Access settings can also be controlled through Group Policy. Non-administrator users can see the current setting but will not be able to change it.

These settings are only enabled if the current user is an administrator on the computer.

I want to be able to turn this off and on so I can avoid this message. I have to click on the allow/deny for each email. I have an application that sends email out. They are greyed out and I cannot change them. How can I change the programmatic access options.